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March 5th

  • Allodynia and hyperalgesia induced by herpes simpl...[Pain. 2000] - PubMed Result: HSV-1 DNA was detected in the dorsal root ganglia from days 2 to 8 post-inoculati on, with a peak effect on day 5. The application of heat-inactivat ed HSV-1 induced no allodynia, hyperalgesia and skin lesion. When started from days 0 or 2, repeated treatment with acyclovir, anti-HSV-1 agent, inhibited the appearance of allodynia, hyperalgesia, eruption and the viral proliferation in the dorsal root ganglia. In contrast, when started from days 5 or 6, acyclovir treatment slightly inhibited the development of skin lesions and the viral proliferation, but not allodynia and hyperalgesia.

December 7th

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