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  • ANGIONEUROTIC EDEMA: Angioneurotic edema produces swelling of the skin, but the swelling is in deeper skin layers and usually lasts for several days instead of hours. Angioneurotic edema usually produces a diffuse, painful swelling in the hands, feet and face, especially around the lips and eyes. The swelling may occur in mucous membranes -- the skin-like tissue that lines the mouth, throat, bronchial tubes and digestive tract, as well. Both angioneurotic edema and urticaria are the result of a disturbance to the circulation in the affected area of the body. The very small blood vessels in that area are dilated and leak clear fluid into the skin in response to histamine release. Leakage into the deeper layers of the skin causes generalized swelling, like a "fat lip," without the appearance of hive. Angioneurotic edema [is] most often produced by an allergic reaction. Medications, foods, inhaled allergens, insect bites and stings, and substances that contact the skin are the most common offenders.

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