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April 23rd

• Effect of yerba mate (Ilex paraguariensis ) tea on topoisomerase inhibition and oral carcinoma cell proliferation. - J Agric Food Chem. 2005 Mar 23: Effect of yerba mate (Ilex paraguariensis ) tea on topoisomerase inhibition and oral carcinoma cell proliferation. Gonzalez de Mejia E, Song YS, Ramirez-Mares MV, Kobayashi H. J Agric Food Chem. 2005 Mar 23

April 16th

• Cytotoxic T cell - Wikipedia, the free encyclopedia: A cytotoxic T cell (also known as TC, CTL, T-Killer cell, cytolytic T cell, CD8 T-cells or killer T cell) belongs to a sub-group of T lymphocytes (a type of white blood cell) that are capable of inducing the death of infected somatic or tumor cells
• In Vitro - Highly cytotoxic and neurotoxic acetogenins of the Annonaceae - Hocquemiller - Université Paris-Sud 11, Châtenay-Malab ry France FR - 2008: Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but discrepancies in the structure/acti vity relationships pled the search for other targets within the whole cell proteome. Combining hemisynthetic work, Cu-catalyzed Huisgen cycloaddition and proteomic techniques we have identified new putative protein targets of squamocin ruling out the previously accepted 'complex I dogma'. These results give new insights into the mechanism of action of these potent neurotoxic molecules.
• In Vitro - Squamocin, a new cytotoxic bis-tetrahydro furan containing acetogenin from Annona squamosa - Chem Pharm Bull (Tokyo) - 1988

April 8th

• In Vitro - Squamocin - a new cytotoxic bis-tetrahydro furan containing acetogenin from Annona squamosa - Fujimoto Tokyo Japan JP - 1988: Title: Squamocin, a new cytotoxic bis-tetrahydro furan containing acetogenin from Annona squamosa. Author: Fujimoto, Y : Eguchi, T : Kakinuma, K : Ikekawa, N : Sahai, M : Gupta, Y K Citation: Chem-Pharm-Bul l-(Tokyo). 1988 Dec; 36(12): 4802-6 Abstract: None Review References: None Notes: None Language: English Publication Type: Journal-Articl e Keywords: Antineoplastic Agents, Phytogenic isolation and purification : Furans isolation and purification : Lactones isolation and purification : Plants, Medicinal analysis URL: No URL associated with this record.

April 6th

• Patent - Cytotoxic annonaceous acetogenins - US7223792 - Filed - Dec 07, 2001: Acetogenins isolated from Annona muricata of the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective cytotoxicity for various human tumor cell lines.

March 9th

• Patent - US7223792 - Cytotoxic annonaceous acetogenins from annona muricata - Holder - Prof Yang-Chang Wu - Kaoshiung Medical University, Taipei, Taiwan, TW - 2001-2007: Acetogenins isolated from Annona muricata of the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective cytotoxicity for various human tumor cell lines. Prof Yang-Chang Wu, Editorial Board, Kaoshiung Medical University, Taipei, Taiwan, Email: yachwu@kmu.edu .tw

March 3rd

• Chemotherapy - Wikipedia, the free encyclopedia

February 14th

• Snake venom types and first aid treatment

February 8th

• Docetaxel - Wikipedia, the free encyclopedia: The main use of docetaxel is the treatment of a variety of cancers after the failure of anthracycline- based chemotherapy.[ 3] Marketing of docetaxel as Taxotere is mainly towards the treatment of breast, prostate and other non-small cell cancers.[4] Clinical data has shown docetaxel to have cytotoxic activity against breast, colorectal, lung, ovarian, prostate, liver, renal, gastric, head and neck cancers, and melanoma.

November 14th

• Cytotoxic substances from plants: Cytotoxic substances are toxic to cells and cause their death. Such compounds are widespread among plants. More importantly, these effects can be used for medical purposes such as suppressing growth of various tumor cells. This chapter provides an overview of the many cytotoxins and the many fungi and plants in which they naturally occur.

November 7th

• In Vivo - Antimalaria and Cytotoxic Properties of Annona Senegalensis Extract, Annonaceae - University of Ibadan, Nigeria - NI - 2006: The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona senegalensis Pers. (Annonaceae) was investigated in this study. The in vivo antimalarial activity of the methanol extract against Plasmodium berghei was assessed using the 4-day suppressive test procedure. The extract of A. senegalensis had intrinsic antimalarial property that were dose ? dependent. At doses of 100mg/kg weight of mice, it produced significant chemosuppressi on of parasitemia (> 57%) when administered orally. It had the highest activity at 800mg/kg weight of mice (91.1%) compared to Chloroquine disphosphate, the standard reference drug which had a chemosuppressi on of 96.2%.
• In Vitro - Actogenins, anthelmintic, antimalarial, antimicrobial, antiprotozoal, and cytotoxic antitumor - University of Tartu, Estonia: The tropical plant family Annonaceae consists of 130 genera and 2300 different species.[1] However, despite of its relatively large size, the plant family is chemically one of the least explored. The discovery of uvaricin (Fig. 1) in 1982, the first of the acetogenins, as an in vivo active antileukemic (P-388) agent, invigorated wide interest in this family.[2]

October 6th

• Most Beta-Cells Die via Inflammatory Cytokines, Not Cytotoxic T-lymphocytes | Full Text (PDF)
• Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes -- Seewaldt et al. 49 (11): 1801 -- Diabetes: Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes

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