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  • How does pregabalin compare to gabapentin in the treatment of neuropathic pain?: Part of the reason why pregabalin requires lower dosages is that it has a much higher bioavailabilit y (90% versus 33-66%) and is rapidly absorbed (peak: 1 hr). Also, plasma concentrations increase linearly with increasing dose.3 This is not true with gabapentin. Gabapentin is slowly absorbed (peak: 3 to 4 hours post-dose) and more importantly, plasma concentrations have been found to have a non-linear relationship to increasing doses. Pregabalin has been found to have distinct pharmacokineti c advantages over gabapentin.3
  • Pharmacokineti cs of gabapentin (Neurontin) and Pregabalin (Lyrica). - CareCure Forums: pregabalin was estimated to be ***4 times*** more effective than gabapentin in patients who responded to treatment. Pregabalin was also ***2.5 times*** more potent than gabapentin in responding patients, as measured by the dose that reduced seizure frequency by 50%. also -- Increasiing amounts of pregabalin is absorbed with increasing oral doses while gabapentin absorption decreases with increasing oral doses.
  • lyrica|pregaba lin potency compared to gabapentin - Google Search: pregabalin has a 6-fold increased potency compared to gabapentin

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