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June 25th
- Tumor microvasculatu re supports proliferation and expansion of glioma-propaga ting cells: Use primary GBM and microvasculatu re and show contact mediated enhancement of growth of GBM
June 22nd
- Wnt-5a-CKI{alp ha} Signaling Promotes {beta}-Catenin /E-Cadherin Complex Formation and Intercellular Adhesion in Human Breast Epithelial Cells -- Medrek et al. 284 (16): 10968 -- Journal of Biological Chemistry: mainly looking at MCF7 cells - in Oncomine data - WNT5A correlates with better survival in breast cancer while WNT5B correlates with worse survival
June 18th
- Vorinostat shows anti-cancer activity in recurrent gliomas: first FDA approved oral anti-cancer agent that inhibits an enzyme, histone deacetylase, that is closely associated with DNA in cells
June 15th
- Ovid: In Vitro Modulation of Microglia Motility by Glioma Cells Is Mediated by Hepatocyte Growth Factor/Scatter Factor.: GL261 cells produce large amounts of HGF/SF and stimulate migration of BV2 microglial cells using this
- Microglia promote glioma migration: Use GL261 cells and isolate fresh microglia from (Balbc - not clear why not C57Bl/6) mice to look and migration
- Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis: Imaging GL261 cells using RFP with a multiphoton!
June 13th
June 10th
- ScienceDirect - Neurochemistry International : ERK Phosphorylatio n in Intact, Adult Brain by ?2-Adrenergic Transactivatio n of EGF Receptors: activation of EGFR in astrocytes by a2 adrenoreceptor . Possible glioma relevance and also general analysis approach for CXCR4 studies in HNSCC (maybe breast?)
June 8th
- The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells -- Ulrich et al. 69 (10): 4167 -- Cancer Research: looking at u373 mg cells mainly but also U87, U251, SNB19, . Reducing stiffness of matrix causes cells to round up. Cells move faster on stiffer matrices, keeping the ligand level constant.
June 7th
June 5th
May 12th
April 25th
- Imaging glioma cell invasion in vivo reveals mechanisms of dissemination and peritumoral angiogenesis: cranial window imaging of RFP labeled GL261 cells in Tie2GFP animals! Cells invade along blood vessels
April 23rd
- Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptiona l Activity -- Rong et al. 69 (6): 2540 -- Cancer Research: increasing tissue factor and coagulation could maybe stimulate intravasation via ErbB2?
April 17th
- Oncogene - EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor: ephrinA5 expression in glioma or stimulation with Fcephrin can reduce EGFR expression and tumorigenicity
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