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March 26th
- Pharmaceutical preparation comprising eicosapentaeno ic acid and/or stearidonic acid - US Patent 6624195 Description: The invention relates to fatty acid treatment in depression. ... While we cannot be certain of the mechanism by which EPA is working, one possibility is that it is inhibiting the enzyme, phospholipase A2. There is considerable evidence that phospholipase (PL) A2 activity is elevated in schizophrenia (Horrobin et al, Schizophrenia Research 1994
- Different effects of n-6 and n-3 polyunsaturate d fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. - J Lipid Res. 2003 Mar: Different effects of n-6 and n-3 polyunsaturate d fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Bousserouel S, Brouillet A, Béréziat G, Raymondjean M, Andréani M. J Lipid Res. 2003 Mar
- Docosahexaenoi c acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. - Wiley InterScience :: JOURNALS :: Journal of Neuroscience Research: Docosahexaenoi c acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. Martin RE. J Neurosci Res. 1998 Dec 15
- The role of eicosanoids in the brain. [Asia Pac J Clin Nutr. 2008] - PubMed Result: The role of eicosanoids in the brain. Tassoni D, Kaur G, Weisinger RS, Sinclair AJ. Asia Pac J Clin Nutr. 2008
- Use of dha, epa or dha-derived epa for treating a pathology associated with cellular oxidative damage invention: USPTO Application #: 20080292681 Title: Use of dha, epa or dha-derived epa for treating a pathology associated with cellular oxidative damage Abstract: The present invention relates to the use of an acid enriched in docosahexaenoi c acid (DHA) or eicosapentaeno ic acid (EPA) or DHA-derived EPA for manufacturing a drug for the treatment of processes that involve associated oxidative damage. In particular, it is for the treatment of processes associated with neurodegenerat ive, ocular, ischaemic and inflammatory pathology, atherosclerosi s, with oxidative damage to DNA and with physical exercise ... The PLA2 releases the DHA from the membrane phospholipids and the LOX converts it into its metabolically active derivatives.
- Fish Oil - The Best Source and Optimal Dosing of this Anti-inflammat ory Nutrient By Douglas MacKay, ND: Because of their health-promoti ng abilities, omega-3 fatty acids have received recognition from some of the top medical organizations in the world including, the American Heart Association, American Diabetes Association, World Health Organization, United Kingdom Scientific Advisory Committee on Nutrition, European Society for Cardiology, and The British Nutrition Foundation.
- Inhibitors of brain phospholipase A2 activity: their neuropharmacol ogical effects and therapeutic importance for the treatment of neurologic disorders. - Pharmacol Rev. 2006 Sep: Inhibitors of brain phospholipase A2 activity: their neuropharmacol ogical effects and therapeutic importance for the treatment of neurologic disorders. Farooqui AA, Ong WY, Horrocks LA. Pharmacol Rev. 2006 Sep
August 23rd
- Oncogene - Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor: an interesting mechanism where arachidonic acid (PLC or PLA product?) could affect PTEN oxidation, resulting in PL-PI3K crosstalk
April 10th
- Developmental Cell -- Chen et al.: an patatin related PLA2 found to be important (in combination with PI3K inhibition) for chemotaxis. And vice versa - PI3K KOs are chemotactic due to the PLA2 still being present
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