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June 23rd

  • Heart study questions diabetes drugs : Nature News | A molecular pathway could explain how a class of drugs leads to heart failure.: A class of diabetes drugs including Avandia is known to raise the risk of heart failure. Researchers who study how tumours balloon in size have discovered one way that enlargement of the heart can lead to heart failure. The work, although mostly done in mice, could help explain why a class of diabetes drugs called thiazolidinedi ones (TZDs) increase the risk of heart failure. A 2007 analysis of Avandia (rosiglitazone ), a TZD made by GlaxoSmithKlin e, suggested that patients taking it are at increased risk of heart attack. Less controversial are data linking TZDs with heart failure, a distinct condition in which the heart cannot pump enough blood through the body. "We already knew if you had heart failure you probably should not be taking these drugs, but this paper provides an additional explanation why," says Clay Semenkovich, an endocrinologis t. The work suggests that a molecule activated by TZDs, called PPAR-?, underlies one aspect of heart failure.

April 8th

  • Diabetes medication pills information: Alpha-Glucosid ase Inhibitor, Biguanide, D-Phenylalanin e derivative, DPP-4 Inhibitor, Meglitinide, Sulfonylurea, Thiazolidinedi one & its side effects.

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July 14th

  • Lab disaster may lead to new cancer drug - Cancer - MSNBC.com: So you're telling me that thiazolidinedi ones (rosiglitazone , pioglitazone, etc.) can cure colon cancer? This should be easy to study: find all your diabetics and see if they have a lower rate of colon cancer than the general population. GSK? Takeda Pharma

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